Asymmetric organocatalytic Michael addition of ketones to vinyl sulfone.
نویسندگان
چکیده
Highly enantioselective organocatalytic Michael addition of ketones to vinyl sulfone catalyzed by a cinchona alkaloid-derived primary amine is reported for the first time; the described synthetic methodology was applied to the synthesis of sodium cyclamate.
منابع مشابه
1,2-Sulfone rearrangement in organocatalytic reactions.
The 1,2-sulfone rearrangement resulting from nucleophilic addition to bis activated vinyl-sulfones has been studied in more detail. Various nucleophiles activated by different types of catalysts (enamine, Brönsted base, thiourea) are able to promote such rearrangement in excellent yields and moderate to excellent enantioselectivities (up to 94% ee). Mechanistic studies have led to a better unde...
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 شماره
صفحات -
تاریخ انتشار 2008